Non-homogenous leukoplakia is a lesion of non-uniform appearance. The color may be predominantly white or a. Homogeneous leukoplakias: the most common type, are uniformly white plaques – common in the buccal (cheek) mucosa and usually of low malignant potential. Oral leukoplakia (leuko=white, plakia=patch) is a white patch in the mouth that There are two main types: homogenous and non-homogenous leukoplakia.

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Natural history of potentially malignant oral lesions and conditions: Hyperkeratosis and altered epithelial thickness may be the only histologic features of a leukoplakia lesion, but some show dysplasia.

Lodi G, Porter S. Non-homogeneous OL can be nodular, verrucous, or speckled erythroplastic Figure 2 Warnakulasuriya et al.

Oral Leukoplakia – an Update

Epub Jul The main objective in oral leukoplakia’s management of care is to detect and to prevent malignant transformation. Treatment Surgical excision, cryosurgery, laser surgery, leuooplakia or systemic retinoids, therapy with mouth rinses with attenuated adenovirus, and photodynamic therapy are possible therapeutics Brennan et al.

At the last world seminar of Oral Medicine about potentially malignant lesions, London 11it has been recommended a binary classification of histological changes without risk or low risk and moderate or severe risk. Sometimes this term is used to describe leukoplakia of the floor of mouth or under the tongue.


Melanin, a pigment naturally produced in oral mucosa, can leak from cells and give a grey color to some leukoplakia lesions. Advertising revenue supports our not-for-profit mission. Brush biopsy was designed for clinical lfukoplakia which initially based on clinical features did not require a biopsy. Textbook of gastroenterology 5th ed.

This can be done using other markers or by the cross examination of two pathologists. After 30 years old [4]. It detects a variety of oral mucosa lesions including linea alba, hairy tongue, leukoedema traumatic ulcers Also, it could offer a more reliable criteria upon which to rely for the selection of patient treatment.

Patches may be removed using a scalpel, a laser or an extremely cold probe that freezes and destroys cancer cells cryoprobe.

Leukoplakia – Wikipedia

Shorten the degrees of dysplasia from five, i. Ultraviolet radiation is believed to be a factor in the development of some leukoplakia lesions of the lower lip, usually in association with actinic cheilitis.

Oral and Maxillofacial Pathology 4 ed. Pathology Microscopically, OL can vary from hyperkeratotic epithelium to lesions with different degrees of dysplasia WHO, ; Brennan et al. A complete and detailed revision on this topic was published by Mithani et al. Diagnosis Most often, your doctor diagnoses leukoplakia by: Oral leukoplakia OL is the most frequent potentially malignant disorder of oral mucosa.


The cause of leukoplakia is unknown. Salinas TJ expert opinion.


In the mouth, the current definition of oral leukoplakia adopted by the World Health Organization is “white plaques of questionable risk having excluded other known diseases or disorders that carry no increased risk for cancer”. When this isn’t effective or if the lesions show early signs of cancer, the homogendous plan may involve: In OL, LOH of the chromosome arms 3p and 9p leukoplaia to be related to a higher risk of malignant transformation.

Initially was used for mucosal lesions of the cervix.

The pooled estimated prevalence rate leuokplakia oral leukoplakia in varied between 1. Some alterations of the oral mucosa can mimic OL, and these lesions must be considered as OL differential diagnosis.

Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. It has been shown that there is high degree of inter-observer variation and poor reproducibility in how dysplasia is graded. This requires experience as it is a difficult skill to learn.