Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Original Article from The New England Journal of Medicine — Effects of Intensive Glucose Lowering in Type 2 Diabetes. UKPDS overview. 1. The UK Prospective Diabetes Study ukpds; 2. • year multicenter RCT -Interventional Trial from to • Intensive.

Author: Vukinos Sasar
Country: Bhutan
Language: English (Spanish)
Genre: Life
Published (Last): 17 May 2005
Pages: 41
PDF File Size: 6.75 Mb
ePub File Size: 10.94 Mb
ISBN: 264-4-97389-983-3
Downloads: 38553
Price: Free* [*Free Regsitration Required]
Uploader: Zuluzil

The increased cost of medication for improving ukprs glucose control or blood pressure control was directly recouped by the lower costs from fewer clinical complications. Diabetes prevention program estusio what is the diabetes prevention program. Previous studies from our laboratory have shown the beneficial effects of a lowcarbohydrate ketogenic diet lckd in patients with type 2 diabetes after its long term administration.

Thus, unlike blood pressure control, intensive glycaemic control is not suitable for all patients, particularly the elderly, or those with existing severe complications.

The Study has shown that insulin is an acceptable treatment when given at an earlier stage of Type 2 diabetes than currently is the practice. Economic evaluations of Type II diabetes. Questionnaires were given to people in the study to assess their quality of life with questions assessing mood, work satisfaction, symptoms and everyday mistakes. Whether intensive glycaemic control should be routinely introduced in type 2 diabetes is more controversial.

UK Prospective Diabetes Study : Protocol

Ukpds diabetes management diabetes mellitus type 2. Key points Figure 4. Cost effectiveness analysis of improved blood pressure control in hypertensive patients with type 2 diabetes: In the last 2 years, the results of several other studies of hypertension which have included patients with diabetes have been published. These results are again reassuring at first sight, but, as with the glucose control study, type 2 errors cannot be excluded; there was a trend in favour of the atenolol treated group.


Estudio ukpds diabetes pdf journals

It also needs to be on a large scale, studying large numbers of patients, to obtain a reliable answer. Clearly, achieving this goal will require aggressive follow up patients in the Estjdio were seen 3 monthlyand this may not be acceptable to all patients.

Age life expectancy comorbidities duration of diabetes risk of hypoglycemia patient motivation patient adherence ada. Effect of intensive bloodglucose control with metformin.

Effect of intensive bloodglucose control with metformin on. One scale demonstrated that poor quality of life is related to complications rather than the treatments given [unpublished].

Using this standard increase in the number of patients with ckd. McCarty D, Zimnet P. The fact that benefits are achieved within 2 or 3 years means that all patients should be treated irrespective of age. There will be handouts on each talk as a take home package on treatment of diabetes. There is concern that sulphonylureas may increase cardiovascular mortality in patients with type 2 diabetes and that high insulin concentrations may enhance atheroma formation.

There is no doubt that aggressive management of blood pressure is important, particularly in reducing macrovascular disease, the main cause of morbidity and mortality in these patients.

Serious side -effects were unusual. The lowcarbohydrate, ketogenic diet lckd may be effective for improving glycemia and reducing medications in patients with type 2 diabetes.

Implications of the united kingdom prospective diabetes study. Intensive bloodglucose control with sulfonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes. Therapeutic implications, study limitations and outstanding questions Figures 5 — 7. Received Mar 15; Accepted Aug Read uk prospective diabetes study ukpds, diabetologia on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.


Both are important, however, obtaining near-normal blood pressure is, in many patients, easier than estidio near-normal blood glucose levels because more different types of therapies are available. In people with Type 2 diabetes that is usually diagnosed in middle age, symptoms ukpcs often be controlled by diet or tablet therapy.

Intensive bloodglucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes ukpds A lowcarbohydrate, ketogenic diet to eestudio type 2 diabetes. Methods from an outpatient clinic, we recruited 28 overweight participants with type 2 diabetes for a 16week singlearm pilot diet intervention trial. Effect of intensive blood-glucose control with metformin etudio complications in overweight patients with type 2 diabetes UKPDS 34 Lancet.

The study showed that intensive blood glucose treatment is acceptable and that better blood glucose control could be obtained than with conventional management. Mortality and survival in type II non-insulin dependent diabetes mellitus.

This would allow early therapy to be given before the processes which lead to complications can operate. Rosiglitazone evaluated for cardiovascular outcomes in oral. Metabolic control and cardiovascular risk factors in type 2.

Strategies for early combination therapy for type 2. Support Center Support Center. Unlike glycaemic control, there was a significant effect on macrovascular as well as microvascular complications, with strokes and heart failure reduced by a half.