BYDUREON PACKAGE INSERT PDF

Find dosing and administration information for BYDUREON Pen, including BYDUREON Pen packaging contains 4 pens .. BYDUREON [package insert]. Learn about BYDUREON® BCiseTM including efficacy, safety, PK profile, and dosing, and available resources, including Important Safety Information. Package Leaflet: Information for the user. Bydureon 2 mg powder and solvent for prolonged-release suspension for injection in pre-filled pen exenatide. Read all.

Author: Yozshuktilar Kezuru
Country: Somalia
Language: English (Spanish)
Genre: Science
Published (Last): 20 November 2008
Pages: 458
PDF File Size: 9.38 Mb
ePub File Size: 6.7 Mb
ISBN: 400-9-21969-981-2
Downloads: 80528
Price: Free* [*Free Regsitration Required]
Uploader: Digis

Burns, diarrhea, fever, infection, surgery, thyroid disease, trauma, vomiting. Regular-release exenatide is available as a pre-filled pen; do not transfer pacckage from the pen to a syringe or a vial. The manufacturer of exenatide provides an insulin glargine dose titration algorithm to aide clinicians when using exenatide with insulin glargine; consult product labels.

This effect may lead to hypoglycemia acutely, followed by hyperglycemia with prolonged pentamidine therapy.

Patients should be monitored for changes in glycemic control while receiving pentoxifylline in combination with antidiabetic agents.

Do not store the bydurfon with the needle on, as the medication may leak out or air bubbles may form in the cartridge. Therefore, the use of exenatide is not recommended in patients with severe GI disease e.

Bydureon (exenatide) dose, indications, adverse effects, interactions from

A selective beta-blocker may be preferred in patients with diabetes mellitus, if appropriate for the patient’s condition. Do not administer by intravenous or intramuscular injection. Monitor blood glucose for needed dosage adjustments with exenatide in diabetic patients whenever a change in either nicotine intake or tobacco smoking status occurs. Patients receiving incretin mimetics should be closely monitored for signs indicating loss of diabetic control when therapy with a hydantoin is instituted.

Based on animal reproduction studies, there may be risks to the fetus from exposure to exenatide during pregnancy, therefore, exenatide should only be used during pregnancy packate the potential benefit justifies the potential risk to the fetus. Lower glucagon concentrations lead to decreased hepatic glucose output and decreased insulin demand. The dosing of antidiabetic agents may require adjustment in patients who receive metoclopramide.

Related Posts  ENTE BUS YATHRA PDF

Although routine monitoring of serum calcitonin is of uncertain value in patients treated with extended-release exenatide, if serum calcitonin isnert measured and found to be elevated, the patient should be referred to an endocrinologist for further evaluation.

PDR Search

Similar absorption is achieved with subcutaneous byduron of exenatide in the abdomen, thigh, or arm. Exenatide should be used with caution in patients receiving oral medications that require rapid gastrointestinal absorption. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion.

A Byetta Pen can be used for up to 30 days after first use. If a dose is missed, administer it as soon as noticed, as long as the next regularly scheduled dose is due at least 3 days later.

Acetaminophen AUC, Cmax, and Byudreon were not significantly changed when acetaminophen was given packate h before exenatide injection.

Minor Tobacco smoking is known to aggravate insulin resistance. After use, properly dispose of used pen needles.

Exenatide is given via subcutaneous administration. If a patient chooses to ingest alcohol, they should monitor packagd blood glucose frequently. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are indert. Exenatide is the first in a new class of antihyperglycemic agents called incretin mimetics.

The risk of hypoglycemia is increased when exenatide is used in combination with insulin secretagogues e. For lixisenatide, the manufacturer recommends taking the OC 1 hour before injection or 11 hours after injection to reduce the effect on absorption. For the pen, insert the needle into your skin. Bismuth Subsalicylate; Metronidazole; Tetracycline: Hyperglycemia has developed in patients with diabetes mellitus following discontinuation of the drug.

If a patient with diabetes ingests alcohol, they packkage be counselled to to avoid ingestion of alcohol on an empty stomach, which increases risk for low blood sugar. Exenatide also slows gastric emptying thereby reducing the rate at which meal-derived glucose appears in the circulation. In patients with ESRD receiving dialysis, exenatide was poorly tolerated due to gastrointestinal side effects nausea, vomiting, diarrhea.

Related Posts  CHUCK PALAHNIUK ROZBITEK PDF

Hold the autoinjector upright with the orange cap toward the ceiling. Patients should be monitored for worsening of glycemic control if therapy with cyclosporine is initiated in patients receiving antidiabetic agents, including incretin mimetics.

Monitor blood glucose more carefully during initiation or discontinuation of hormone replacement or hormonal contraceptive treatment. After that, patients can resume their usual dosing schedule of once every 7 days weekly. It is not known whether monitoring serum calcitonin or performing thyroid ultrasounds will diminish human risk of thyroid C-cell tumors.

Some beta-blockers, particularly non-selective beta-blockers such as propranolol, have been noted to potentiate insulin-induced hypoglycemia and a delay in recovery of blood glucose to normal levels. Minor Phenothiazines, especially chlorpromazine, may increase blood glucose concentrations.

Indapamide can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Inject subcutaneously into the thigh, abdomen, or upper arm. Diabetic patients should be monitored for potential hypoglycemic reactions while on linezolid. The manufacturer of digoxin recommends measuring serum digoxin concentrations prior to initiation of exenatide.

Recommendations will be communicated once the review is complete; continue to consider precautions related to pancreatic risk until more data are available.

In mice, exenatide administered during gestation and lactation caused increased neonatal deaths at doses that approximate clinical exposures at the MRHD.

Extended-release injection suspension Bydureon single-dose Pen: It is acceptable for the injections to be in the same body region but the injections should NOT be adjacent to each other. Pull the needle cover straight off byduroen pen for use.

Even if the disposable needle is changed, sharing may result in transmission of hepatitis viruses, HIV, or other blood-borne pathogens.